Operation ‘Allied force’: What will it take to make the UK's fragile air power capability more robust?

What Will It Take to Cure HIV?

Investigational strategies to attempt HIV cure or remission include very early initiation of antiretroviral therapy to limit the latent HIV reservoir and preinfection vaccination. In the setting of viral suppression, strategies include reactivation of latently infected cells (eg, through "shock" therapy with histone deacetylase inhibitors or other agents); use of broadly neutralizing antibodies...

What will it take to stop obesity?

O besity has reached epidemic proportions in industrialized countries like the United States, resulting in increased morbidity and mortality, decreased productivity and function, and soaring health care costs. In the United States, the explosion of fast food restaurants, with their high-fat, supersized portions containing little nutritive value, is considered a major contributor to obesity. In ...

Immunotherapy coming of age: what will it take to make it standard of care for glioblastoma?

With the recent approval by the FDA of an immunotherapy for prostate cancer and another positive immunotherapy trial in melanoma, immunotherapy may finally be coming of age. So what will it take for it to become part of the standard treatment for glioblastoma? To put this question into perspective, we summarize critical background information in neuro-immunology, address immunotherapy clinical ...

What will it take to end AIDS in the Americas?

What does it take to make the perfect clot?

The coagulation process has been conceptualized as being primarily dependent on adequate levels of the coagulation proteins. This concept was based on the clear relationship between the bleeding tendency and factor levels in hemophilia. The field is now evolving toward conceptualizing coagulation as being actively regulated by the specialized cellular components of the process. Rather than conc...